1. Oxidative stress and inflammatory disease

Antioxidant and anti-inflammatory protection of vascular endothelial cells by synthetic mimics of glutathione peroxidase. Chaudière J,Moutet M, d’Alessio P. C.R. Soc. Biol. 1996;189:861-882.

Pharmacological modulation of endothelial cytoskeleton induced by hydrogen peroxide and TNF-a. d’Alessio P, Moutet M, Marsac C, Chaudière J. C.R. Soc. Biol.1996;190:289-297.

Pharmacological inhibition of endothelial cytoskeleton alterations induced by hydrogen peroxide and TNF-a d’Alessio P, Moutet M, Marsac C, Chaudière J. In: “Oxidative Stress, Cancer, AIDS, and Neurodegenerative Diseases”. Marcel Dekker, Inc., N.Y., Montagnier, Olivier, and Pasquier eds, 1997, pp 313-321.

Photoageing of the skin. Giacomoni P, d’Alessio P. Open questions in photobiology IV. Photoaging of the skin J. Photochem. Photobiol. B. Biol. 1996;33:267-272.

Skin ageing: The Relevance of Antioxydants. Giacomoni P, d’Alessio P. In: “ Molecular Gerontology ” Suresh I.S.Rattan and Olivier Toussaint eds, 1996, pp 177-192.

Skin aging: Mechanisms and Possible Interventions. Giacomoni P, d’Alessio P. In: “Advances in Anti-Aging Medecine”, vol. 2, Academy of Anti-Aging Medecine eds, 1997.

ICAM-1 and VCAM-1 expression induced by TNF-a are inhibited by a glutathione peroxidase mimic. d’Alessio P, Moutet M, Darquenne S, Coudrier E, Chaudière J. Free Rad.Biol.Med. 1998;24:979-987.

GPx mimics prevent TNF-a and neutrophil-induced endothelial alterations. Moutet M, d’Alessio P, Malette P, Chaudière J. Free Rad.Biol.Med. 1998;25:270-281.

ICAM-1 and VCAM-1 expression induced by TNF-a are inhibited by a glutathione peroxidase mimic. d’Alessio P, Moutet M, Darquenne S, Coudrier E, Chaudière J. In: “Vascular Endothelium : Mechanisms of Cell Signaling” J.D.Catravas, A.D.Callow, U.S.Ryan eds, Nato Science Series IOS Press, 1999, pp 220-225.

Regulation of ICAM-1/CD54 expression on human endothelial cells by hydrogen peroxide involves inducible NO synthase. Sadeghi Zadeh M, Kolb JP, Geromin D, D’Anna R, Boulmerka A, Marconi A, Dugas B, Marsac C, d’Alessio P. J Leukocyte Biol. 2000;67:327-334.

2. Vascular endothelium and cancer (HPV-16 E7)

HPV16-E7 but not E6 oncogenic protein triggers both cellular immunosuppression and angiogenic processes. LeBuanec H, D’Anna R, Lachgar R, Zagury JF, Bernard J, Ittelé D, d’Alessio P, Hallez S, Giannouli C, Burny A, Bizzini B, Gallo RC, Zagury D. Biomed. Pharmacother. 1999;53:424-431.

Human Papillomavirus-16-E7 Oncoprotein Enhances the Expression of Adhesion Molecules in Cervical Endothelial Cells but not in Human Umbilical Vein Endothelial Cells. D’Anna R, Le Buanec H, Bizzini B, Burny A, Giannouli C, Zagury JF, Gallo RC, Zagury D, d’Alessio P. J Human Virol. 2001;4:85-95.

Selective activation of cervical microvascular endothelial cells by human papillomavirus 16-E7 oncoprotein. D’Anna R, Le Buanec H, Alessandri G, Caruso A, Burny A, Gallo R, Zagury JF, Zagury D, d’Alessio P. J Nat Cancer Inst. 2001;93:1843-1851.

3. Endothelium as pharmacological target

Endothelium as pharmacological target. d’Alessio P. Curr. Op. Invest. Drugs. 2000;2:1720-1724.

Oxidative stress and endothelial senescence. Marconi A, d’Alessio P. In : Proceedings Free Rad Res International, 2003, pp 125-128.

Naftidrofuryl-driven regulation of endothelial ICAM-1 involves Nitric Oxide. Marconi A, Darquenne S, Boulmerka A, Mosnier M, d’Alessio P. Free Rad.Biol.Med. 2003;34:616-625.

Aging and the endothelium. d’Alessio P. J Exp Gerontol. 2004;39:165-171.

Antioxidant Betalains from Cactus Pear (Opuntia Ficus Indica) inhibit endothelial ICAM-1 expression. Gentile C, Tesoriere L, Allegra M, Livrea MA, d’Alessio P. Annals NYAcadSci, 2004, vol.1028, “Signal Transduction and Communication in Cancer Cells”, pp 481-486.

d’Alessio P, Cellular stress and aging, 2005 Nouvelle Revue d’Aromathérapie, Springer eds.

Tripterine, inhibits the expression of adhesion molecules in activated endothelial cells. Zhang D, Marconi A, Xu LM, Yang CX, Sun GW, Feng XL, Xu SM, Ling CG, Qin WZ, Uzan G, d’Alessio P. J Leukocyte Biol. 2006;80:309-319.

New pharmaceutical interventions in aging. Bisson JF, Menut C, d’Alessio P. Rejuv Res. 2008;11:399-407.

Fasciatherapy combined with pulsology induces changes in blood turbulence potentially beneficial for the Endothelium. Queré N, Noël E, Lieutaud A, d’Alessio P. J Bodyw Mov Ther. 2009;13:239-245.

Is internet-based nutritional coaching feasible in older adults? Tauchert K, Buccolini F, d’Alessio PA, Melini A, Lochs H, Valentini L. Clin Nutr. 2010;Supp 5:124.

New anti-inflammatory molecule AISA 5203-L promotes adaptive strategies in cell aging. d’Alessio P. In : “Adaptation Biology and Medicine, Cell Adaptations and Challenges”, P. Wang, C.-H.Kuo, N. Takeda and P.K. Singal eds, Narosa Publishing House Ltd., 6 : 369-378, 2011.

New Targets for the Identification of an Anti-Inflammatory Anti-Senescence Activity. d’Alessio P, Bennaceur-Griscelli A, Ostan R, Franceschi C. In : « Senescence », ISBN 978-953-308-28-6 chap. 2: 647-666, In Tech 2012.

4. AISA’s pre-clinical and first-in human studies

Gender differences in response to dietary supplementation by Orange Peel Extract in elderly people in the RISTOMED study: impact on Quality of Life and inflammation. d’Alessio P, Ostan R, Valentini L, Bourdel-Marchasson I, Pinto A, Buccolini F, Franceschi C, Bené M.C. PRIME 2012;July/August:30-37.

Cellularité et extracellularité. Le système multi-fibrillaire : du cytosquelette au tissu conjonctif. d’Alessio PA. Annales de chirurgie plastique esthétique 2012;57-5:497-501.

On the way of longevity: how to counteract neurodegenerative disease » d’Alessio P, Ostan R, Capri M, Franceschi C.^, In : “Senescence and senescence – related disorders”, Zhiwei Wang & Hiroyuki Inuzuka eds., INTECH, 2013.

Oral administration of d-Limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humans. d’Alessio PA, Ostan R, Bisson JF, Schulzke JD,  Ursini MV, Béné MC. Life Sciences. 2013;92:1151-1156.

Skin repair properties of Perillyl Alcohol in murine models. d’Alessio PA, Mirshahi M, Bisson JF, Béné MC. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2014;13:29-35.

Anti-stress effects of d-Limonene and its metabolite perillyl alcohol. d’Alessio PA, Bisson JF, Béné MC. Rejuvenation Res. 2014;17:145-149.

Clinical efficacy of orange peel extract in psoriasis. Rossi A, Béné, MC, Carlesimo M, Garelli V, Fortuna MC, d’Alessio PA. Global J Dermatol Venerol. 2015;3:1-4.

Anti-inflammatory and skin repair treatments with d-Limonene. d’Alessio PA, Menut C, Lejay J, Bisson JF, Béné MC. PRIME. November 2015; 19-25.

Impact of diet and nutraceutical supplementation on inflammation in elderly people. Results from the RISTOMED study, an open-label randomized control trial. Ostan R, Béné MC, Spazzafumo L, Pinto A, Donini L, Pyren F, Charrouf Z, Valentin L, Lochs H, Bourdel-Marchasson I, Blanc-Bisson C, Buccolini F, Brigidi P, d’Alessio PA. Clin Nutr. 2016;35:812-818.

Les marqueurs du vieillissement biologique « Markers of biological aging ». d’Alessio PA. Corresp. Onco-Hématol. 2018;13:18-20.

Salutogenesis and beyond. d’Alessio PA, Dermatol Ther 2019; 32:e1278.

Platelet rich plasma in androgenic alopecia : a systematic review. Lotti^, T, Goren A, Verner I, d’Alessio PA, Franca K. 2019, DTH, doi.org/10.1111/dth. 12837

AISA can control the inflammatory facet of SASP. d’Alessio PA, Béné MC. Mech Ageing Dev. 2020 Jan 2;186:111206. doi: 10.1016/j.mad.2019.111206.

The Gut-brain axis is relevant to skin aging. d’Alessio PA PRIME, July 2020, Vol. 10 Issue 4, 36-42.

Quality of Life: Psychological Symptoms—Effects of a 2-Month Healthy Diet and Nutraceutical Intervention; A Randomized, Open-Label Intervention Trial (RISTOMED) Bourdel-Marchasson I, Ostan R, Regueme SC, Pinto A, Pryen F, Charrouf Z, d’Alessio PA, Roubaud Baudron C, Guerville F, Durrieu J, Donini LM, Franceschi C and Valentini V. Nutrients 2020, 12, 800; doi:10.3390/nu12030800

d-Limonene challenging anti-inflammatory strategies. d’Alessio PA, Béné MC and Menut C. AIMS Molecular Science April 2022 9 (2): 46-65. https://www.aimspress.com/journal/Molecular